Additive Manufacturing of Multi?Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth

Medical devices, such as silicone-based prostheses designed for soft tissue implantation, often induce a suboptimal foreign-body response which results in hardened avascular fibrotic capsule around the device, leading to patient discomfort or implant failure. Here, it is proposed that additive manufacturing techniques can be used deposit durable coatings with multiscale porosity on surfaces promote optimal integration. Specifically, “liquid rope coil effect”, exploited via direct ink writing, create controlled macro open-pore architecture, including over highly curved surfaces, while adapting atomizing spray deposition of silicone microporous texture. The potential tailor degree integration and vascularization using these fabrication demonstrated through subdermal submuscular implantation studies rodent porcine models respectively, illustrating coating's applications both traditional prosthetics active drug-eluting devices.